NOVEL SYSTEM USES PROBASIN-BASED PROMOTER, TRANSCRIPTIONAL SILENCERS AND AMPLIFICATION LOOP TO INDUCE HIGH-LEVEL PROSTATE EXPRESSION

Novel system uses probasin-based promoter, transcriptional silencers and amplification loop to induce high-level prostate expression

Abstract Background Despite several effective treatment options available for prostate cancer, it remains the second leading cause of cancer death in American men.Thus, there is a great need for new treatments to improve outcomes.One such hard steel shot strategy is to eliminate cancer through the expression of cytotoxic genes specifically in prost

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Apparent molar volume anomaly in water-dimethyl sulfoxide liquid mixtures. Molecular dynamics computer simulations

We have studied the composition dependence of density of liquid water-DMSO mixtures at different temperatures by using the isobaric-isothermal (NPT) molecular dynamics computer simulations.The non-polarizable semi-flexible, P1 and P2 models for the DMSO molecule combined with the TIP4P-2005 water model are considered.The excess mixing volume and th

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